The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Elenco: Tobey Maguire , Kirsten Dunst , James Franco , Thomas Haden Church , Topher Grace , Bryce Dallas Howard , Rosemary Harris , James Cromwell , J.K. Simmons , Theresa Russell , Dylan Baker , Bill Nunn , Elizabeth Banks , Ted Raimi , Perla Haney-Jardine , Willem Dafoe , Cliff Robertson , Elya Baskin , Mageina Tovah , Michael Papajohn , Joe Manganiello , Stan Lee , Bruce Campbell , Christopher Young , Grant Curtis , Daniel Gillies , John Paxton , Becky Ann Baker , Steve Valentine , Hal Fishman , Lucy Gordon , Toni Wynne , Andre B. Blake , Tim Maculan , Marc Vann , Joe Bays , Gregg Daniel , Rogelio T. Ramos , Timothy Patrick Quill , Kathryn Bryding , Joe Virzi , Bill E. Rogers , Michael Alexander , April Parker-Jones , Edward Padilla , Robert Curtis Brown , Paul Terrell Clayton , Carolyn Neff , Christina Cindrich , Sonya Maddox , Derrick 'Phoenix' Thomas , Jessi Collins , Michael McLaughlin , Anne Gartlan , Emilio Rivera , Keith Woulard , Reynaldo Gallegos , Jim Coope , Dean Edwards , Margaret Laney , Aimee Miles , Tanya Bond , Mark Kubr , Tony Besson , Ramon Adams , A.J. Adelman , Angelis Alexandris , Dawn Marie Anderson , Frank Anello , Anya Avaeva , David Backus , Tiffany L. Baker , Sujeilee Candele , Michael Ciesla , Irina Costa , John Crann , Crystal Marie Denha , Amy V. Dewhurst , Paul Edney , Natalie Fabry , Keith Fausnaught , Shaun Patrick Flynn , Logan Fry , Kevin Fung , Tony Galtieri , Chuck Gerena , Brian Hopson , Claude Jay , Julie Jei , Andrew James Jones , Natalie Jones , Christopher Jude , Brittany Krall , Alyssa Lakota , Pierangeli Llinas , Bernadette Lords , Sandrine Marlier , Laura McDavid , Natalie McNeil , Daniel Mignault , Martha Millan , Michele-Nanette Miller , Claudia Katz Minnick , Robert Myers , Joseph O'Brien , Jen Oda , Anjelia Pelay , Nick Poltoranin , Vanessa Reseland , La Rivers , Bria Roberts , Vanessa Ross , Brenna Roth , Shade Rupe , Arick Salmea , Eric Shackelford , Daniel Shafer , Abbey Skinner , Kristin Somo , Jennifer Sparks , Christopher Stadulis , Jimmy Star , Arne Starr , Liam Stone , Tajna Tanovic , Aija Terauda , Brigid Turner , Evelyn Vaccaro , Nick Vlassopoulos , Sincerely A. Ward , Silq Webster , Graig F. Weich , Fredrick Weiss , Jennifer Weston , Trenton Willey , Ray Wineteer , Emily Eckes .