The series revolves around the titular room and some of the everyday items from that room which possess unusual powers. The show's protagonist, Joe Miller, is searching for these objects to rescue his daughter, Anna, who has disappeared inside the Room. Once a typical room at a 1960s motel along U.S. Route 66, the Lost Room exists outside of normal time and space since 1961, when what is only referred to as "the Event" took place.
Elenco: Julianna Margulies , Margaret Cho , Peter Krause , Kevin Pollak , Elle Fanning , Tim Guinee , Ann Cusack , April Grace , Peter Jacobson , Chris Bauer , Harriet Sansom Harris , Nicholas Guilak , Chris Monberg , Dennis Christopher , Ewen Bremner , Roger Bart , Benjamin Petry .