Agents Napoleon Solo (American) and Illya Kuryakin (Russian) work for U.N.C.L.E., a secret intelligence service working under the auspices of the U.N. Their immediate superior is Mr. Waverly (British), and they operate out of a secret base beneath the streets of New York City, and accesses through several cover business such as Del Floria's Tailor Shop and the Masque Club.

U.N.C.L.E.'s primary nemesis was THRUSH, an organization dedicated to taking over the world. Like U.N.C.L.E., THRUSH used up-to-date spy equipment and advanced technology to complete its conquest.
Elenco: Robert Vaughn , David McCallum , Leo G. Carroll .