V-Wars revolves around Dr. Luther Swann, who enters a world of horror when a mysterious disease transforms his best friend, Michael Fayne, into a murderous predator who feeds on other humans. As the disease spreads and more people are transformed, society fractures into opposing camps pitting normal people against the growing number of these vampires. Swann races against time to understand what's happening, while Fayne rises to become the powerful underground leader of the vampires.